Christiaan de Leeuw

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Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets - Nature Genetics

Jun 3, 2024 | nature.com | Oleksandr Frei |Guy Hindley |Espen Hagen |Nadine Staples Parker |Olav B. Smeland |Christiaan de Leeuw | +2 more

AbstractWhile genome-wide association studies are increasingly successful in discovering genomic loci associated with complex human traits and disorders, the biological interpretation of these findings remains challenging.
Genetic overlap between schizophrenia and height implicates pituitary and immune response

Apr 12, 2024 | medrxiv.org | Cato Romero |Christiaan de Leeuw |Marijn Schipper |Rachel M. Brouwer

C.d.L is funded by Hoffman-La Roche. The other authors declare no competing interests. C.R., D.P. and S.v.d.S were funded by NWO Gravitation: BRAINSCAPES: A Roadmap from Neurogenetics to Neurobiology (grant no. 024.004.012 [to D.P.]). D.P. and C.d.L. were funded a European Research Council advanced grant (no. ERC-2018-AdG GWAS2FUNC 834057 [to D.P.]). M.P.v.d.H. is supported by NWO VIDI Grant 452-16-015 and the ERC Consolidator of the European Research Council Grant 101001062.
Mapping the genetic evolutionary timeline of human neural and cognitive traits

Sep 28, 2023 | biorxiv.org | Ilan Libedinsky |Yongbin Wei |Christiaan de Leeuw |James K. Rilling

AbstractHuman evolution is characterised by extensive changes of body and brain, with perhaps one of the core developments being the fast increase in cranial capacity and brain volume. Paleontological records are the most direct method to study such changes, but they can unfortunately provide a limited view of how 'soft traits' such as brain function and cognitive abilities have evolved in humans.
On the interpretation of transcriptome-wide association studies

Sep 7, 2023 | journals.plos.org | Christiaan de Leeuw |Josefin Werme |Jeanne E. Savage |Wouter J. Peyrot

Loading metrics Open Access Peer-reviewedResearch Article ? This is an uncorrected proof. Citation: de Leeuw C, Werme J, Savage JE, Peyrot WJ, Posthuma D (2023) On the interpretation of transcriptome-wide association studies. PLoS Genet 19(9): e1010921. https://doi.org/10.1371/journal.pgen.1010921Editor: Heather J. Cordell, Newcastle University, UNITED KINGDOMReceived: May 4, 2023; Accepted: August 15, 2023; Published: September 7, 2023Copyright: © 2023 de Leeuw et al.
Local Genetic Sex Differences in Quantitative Traits

May 4, 2023 | biorxiv.org | Emil Uffelmann |Christiaan de Leeuw |Danielle Posthuma |Vrije Universiteit Amsterdam

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On the interpretation of transcriptome-wide association studies

May 3, 2023 | biorxiv.org | Christiaan de Leeuw |Josefin Werme |Jeanne E. Savage |Wouter J. Peyrot

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Genetic timeline of human brain and cognitive traits

Feb 6, 2023 | biorxiv.org | Ilan Libedinsky |Yongbin Wei |Christiaan de Leeuw |James K. Rilling

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