Emine Kilic Bagir

Mar 9, 2023 | frontiersin.org | Sheila Spada |Sanjay Pandey |Giuseppe Schepisi |Emine Kilic Bagir

IntroductionCancers of the kidney and renal pelvis are anticipated to occur in 79,000 individuals in the United States in 2022, the majority of these cases constituting renal cell carcinoma (RCC) (1). RCC is a diverse disease comprising multiple biologically distinct histological features. The most frequent histological type (representing 70%-80% of cases) is clear cell RCC (ccRCC), which is driven by alterations in the Von Hippel-Lindau (VHL) gene (2).

Mar 9, 2023 | frontiersin.org | Sheila Spada |Sanjay Pandey |Giuseppe Schepisi |Emine Kilic Bagir

IntroductionCancers of the kidney and renal pelvis are anticipated to occur in 79,000 individuals in the United States in 2022, the majority of these cases constituting renal cell carcinoma (RCC) (1). RCC is a diverse disease comprising multiple biologically distinct histological features. The most frequent histological type (representing 70%-80% of cases) is clear cell RCC (ccRCC), which is driven by alterations in the Von Hippel-Lindau (VHL) gene (2).