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Jun 26, 2024 | 
biocompare.com | Emma Easthope
Although manual pipetting has long been the standard method for accurate liquid transfer, automated pipetting systems are seeing increased use across a broad range of research applications. This is due to the many advantages that automated pipetting systems provide, which can streamline laboratory workflows and improve productivity. The following are our top five reasons to automate manual pipetting.
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Jun 18, 2024 | 
biocompare.com | Emma Easthope
Enzyme-linked immunosorbent assays (ELISAs) are widely used for quantifying protein biomarkers, cytokines, and other molecules in biological matrices. For accurate and consistent results, it is essential to validate ELISA performance based on stringent acceptance criteria and quality control standards. This article delves into some of those factors.
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Apr 30, 2024 | 
biocompare.com | Emma Easthope
In recent years, adeno-associated virus (AAV) vectors have emerged as the leading delivery platform in clinical gene therapy. This is due to their broad tissue tropism, low immunogenicity, and stable long-term expression, which make AAV gene therapy applicable to a broad range of indications.
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Mar 25, 2024 | 
biocompare.com | Emma Easthope
Enzyme-linked immunosorbent assay (ELISA) is considered the gold standard of immunoassays for the high specificity and sensitivity it provides. Although researchers may choose to develop an ELISA in-house, ready-to-use ELISA kits can save time and reduce the risk of errors—provided they have been properly validated. By basing its ELISA validation process on four core performance indicators, HUABIO ensures that its ready-to-use ELISA kits deliver precise and reproducible results that you can trust.
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Mar 21, 2024 | 
biocompare.com | Emma Easthope
Organoid technology has been widely adopted for drug discovery, where it offers more physiologically relevant pharmacology data than traditional two-dimensional (2D) cell models and can reduce or potentially replace animal testing. This article provides a brief overview of organoid technology, including its advantages and applications, before noting some key challenges and ways in which these are being overcome.
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Jan 24, 2024 | 
biocompare.com | Emma Easthope
In-cell Westerns are a powerful and versatile technique for studying cellular behaviors at a molecular level. By combining the specificity of a traditional Western blot with the high-throughput nature of an ELISA, in-cell Westerns let researchers capture even the most subtle variations in protein expression, provided they are properly designed. What are in-cell Westerns?
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Nov 6, 2023 | 
biocompare.com | Emma Easthope
CO2 incubators provide an optimal environment for cell growth that can also promote the growth of contaminants. Because contamination manifests in different ways, modern CO2 incubators feature a range of specialized solutions for its prevention. This article highlights some of the contamination prevention strategies and technologies to consider when searching for a CO2 incubator.
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Oct 19, 2023 | 
biocompare.com | Emma Easthope
Recombinant proteins have several advantages over their naturally occurring counterparts, including higher yields, more consistent batch-to-batch performance, and an unlimited long-term supply. However, certain features associated with the amino acid sequence may hinder the expression and purification of recombinant proteins. This highlights the importance of having a robust production strategy in place. Importance of recombinant proteinsRecombinant proteins have broad utility.
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Sep 28, 2023 | 
biocompare.com | Emma Easthope
In 2009, Sato et al. published a landmark study showing that adult intestinal stem cells could form complex 3D structures in vitro, each containing multiple cell types matching the organ source. Termed organoids, these have since become essential tools for drug discovery and development by serving as more physiologically relevant alternatives to human cell lines and animal disease models.
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Sep 28, 2023 | 
biocompare.com | Emma Easthope
Real-time, label-free protein binding analysis has long been considered challenging, especially for new or inexperienced users. However, the development of intuitive modern systems for performing techniques such as biolayer interferometry (BLI) and surface plasmon resonance (SPR) has altered this perception, leading to label-free detection methods being widely adopted in the past few decades.
