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Biocompare (www.biocompare.com) stands out as a top source for the latest product details, reviews, and innovations for life scientists. By leveraging extensive expertise in life science products and cutting-edge technologies, Biocompare offers a vibrant and relevant online marketplace for scientific information. Created by scientists for scientists, Biocompare aims to deliver free and efficient services to life science researchers, helping them discover and understand the technologies that fuel their research. The platform features specialized search tools, articles, product reviews, webinars, videos, and technology highlights, all crafted to ensure Biocompare is a reliable and thorough source of product information. Biocompare is dedicated to supporting the life science community by continuously enhancing its online services to make product discovery and technology learning easier.

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Articles

Advanced Antibody Validation Strategies to Ensure Scientific Reproducibility

1 month ago | biocompare.com | Emma Mason

Although there are millions of antibodies available commercially, some are better validated than others. Choosing the right antibody and confirming that it works for your application and target is critical for generating reproducible results. This article looks at some of the antibody validation strategies used by trusted vendors and suggests how you can implement these methods in your own lab.
Excellent CD14 ELISA Kit From BosterBio for Barrier Dysfunction

Aug 8, 2024 | biocompare.com | Sweta Ghosh

CD14 (sCD14), released by macrophages on stimulation with endotoxin, has been used as a marker of gut hyperpermeability. In our study with DSS, we measured the gut permeability to evaluate barrier dysfunction.
Advancing CNV Detection with Digital PCR

Jul 10, 2024 | biocompare.com | Benjamin Atha

Digital PCR (dPCR) is an advanced approach for the absolute quantification of specific DNA and RNA sequences by using partitioned amplification reactions. This method is an adaptation of traditional PCR techniques, offering improved precision, sensitivity, and accuracy. Some advantages of dPCR over other quantification methods include independence from standard curves, higher tolerance to PCR inhibitors, and the capability to detect low-abundance targets.
Assessing Cellular PARylation: Convenient ELISA-Based Methods

Jun 27, 2024 | biocompare.com | Tiffany Yesavage

Post-translational modifications—including phosphorylation, methylation, acetylation, ubiquitylation, and glycosylation—are covalent processes that alter the function of proteins.1 PARylation is another post-translational modification of emerging interest associated with inflammation, metabolism, and cell death.1 Although PARylation often occurs at very low levels, convenient commercial assays allow researchers to measure this phenomenon in cells.
Top Five Reasons to Automate Manual Pipetting

Jun 26, 2024 | biocompare.com | Emma Easthope

Although manual pipetting has long been the standard method for accurate liquid transfer, automated pipetting systems are seeing increased use across a broad range of research applications. This is due to the many advantages that automated pipetting systems provide, which can streamline laboratory workflows and improve productivity. The following are our top five reasons to automate manual pipetting.
Critical Tests to Consider for ELISA Validation

Jun 18, 2024 | biocompare.com | Emma Easthope

Enzyme-linked immunosorbent assays (ELISAs) are widely used for quantifying protein biomarkers, cytokines, and other molecules in biological matrices. For accurate and consistent results, it is essential to validate ELISA performance based on stringent acceptance criteria and quality control standards. This article delves into some of those factors.
Automated Quality Control of Isolated Nuclei Enhances Single-Cell Genomics

May 27, 2024 | biocompare.com | Benjamin Atha

Single-cell sequencing represents a major advancement in genomics, offering researchers the ability to discern cellular heterogeneity at unprecedented resolution. For effective single-cell experiments, proper sample isolation and nuclei counting are required. Automated cell counters have become essential components of this workflow, providing reliable quantification across diverse sample types.
Streamlining the AAV Purification Process

Apr 30, 2024 | biocompare.com | Emma Easthope

In recent years, adeno-associated virus (AAV) vectors have emerged as the leading delivery platform in clinical gene therapy. This is due to their broad tissue tropism, low immunogenicity, and stable long-term expression, which make AAV gene therapy applicable to a broad range of indications.
Single-Cell Multiomics Is Advancing Cancer Research

Apr 25, 2024 | biocompare.com | Bryan Gonzalez |Bryan J. González |Nan Wang

Single-cell multiomics analysis—making measurements in more than one modality simultaneously from single cells (DNA and RNA, or RNA and protein expression, for example) —is quickly becoming an important cancer-fighting tool. Single-cell multiomics is important for revealing cellular heterogeneity in the tumor microenvironment (TME), a sophisticated ecosystem of interacting tumor cells, immune and non-immune cells, and extracellular matrix.
Advances in Cell Cycle Analysis

Mar 28, 2024 | biocompare.com | Michael Scott Long

Chromosome segregation, cell division, and all other processes of cell proliferation are central to cancer progression, aging, the success of stem cell therapies, and many other research fields. The cell cycle is highly coordinated and regulated, as well as adaptive and heterogeneous on the single-cell level (Stallaert et al., 2022). Accordingly, computational tools will benefit such lines of inquiry, as in cell cycle transcriptome dynamics (Chervov and Zinovyev, 2022).