Enhancing naloxoneBy

Jul 30, 2024 | science.org | Samuel Chivers |Enhancing naloxoneBy |John Foley |Mary Andrade

Editor’s summaryChronic pain is associated with both obstructive sleep apnea and sleep deprivation, which is a consequence of sleep apnea. Chivers et al. found that mice exposed during sleep to chronic episodes of hypoxia—but not those merely roused from sleep as often—were more sensitive to heat and touch. Hypoxia activated peripheral macrophages in the circulation and promoted their recruitment into sensory nerve tissues, whose sensitivity was increased by macrophage-released cytokines.

Jul 30, 2024 | science.org | Samuel Chivers |John Foley |Enhancing naloxoneBy

Editors' ChoiceGPCR SIGNALINGJohn F. Foley https://orcid.org/0000-0003-0395-5390Authors Info & AffiliationsAbstractA negative allosteric modulator of the μ-opioid receptor enhances the efficacy of naloxone.