Samuel Chivers

Jul 30, 2024 | science.org | Samuel Chivers |Enhancing naloxoneBy |John Foley |Mary Andrade

Editor’s summaryChronic pain is associated with both obstructive sleep apnea and sleep deprivation, which is a consequence of sleep apnea. Chivers et al. found that mice exposed during sleep to chronic episodes of hypoxia—but not those merely roused from sleep as often—were more sensitive to heat and touch. Hypoxia activated peripheral macrophages in the circulation and promoted their recruitment into sensory nerve tissues, whose sensitivity was increased by macrophage-released cytokines.

Jul 30, 2024 | science.org | Samuel Chivers |John Foley |Enhancing naloxoneBy

Editors' ChoiceGPCR SIGNALINGJohn F. Foley https://orcid.org/0000-0003-0395-5390Authors Info & AffiliationsAbstractA negative allosteric modulator of the μ-opioid receptor enhances the efficacy of naloxone.

Jul 20, 2023 | civilserviceworld.com | Jim Dunton |Samuel Chivers

As with a number of recent publications on the political and constitutional arrangements of the UK, Ian Dunt attempts to take a complicated and ill-understood topic and make it digestible for all audiences. His thorough research is evidenced with a short glance at the acknowledgements section, which presents a snapshot of the great and the good of Westminster, academia and politics.