Enrique Goñi

Jul 24, 2023 | nature.com | Aina Maria Mas |Enrique Goñi |Aida Arcas |Luisa Statello |Dipika Gupta |Jernej Ule | +3 more

Cell lines, growth conditions, and culture treatmentsHCT116 cells (CCL-247) were cultured in RPMI-1640 (GIBCO), and U2OS cells (HTB-96) in DMEM (GIBCO), all mediums supplemented with 10% fetal bovine serum (GIBCO) and 1x penicillin/streptomycin (Lonza), and maintained at 37 ˚C and 5% CO2.

Mar 7, 2023 | biorxiv.org | Aina Maria Mas |Enrique Goñi |Aida Arcas |Luisa Statello

AbstractCells must coordinate the activation of thousands of replication origins dispersed throughout their genome. Active transcription is known to favor the formation of mammalian origins, although the role that RNA plays in this process remains unclear. We show that the ORC1 subunit of the human Origin Recognition Complex interacts with RNAs transcribed from genes with origins in their transcription start sites (TSSs), displaying a positive correlation between RNA binding and origin activity.

Feb 5, 2023 | retinatendencias.com | Enrique Goñi

Algunas de las mayores revoluciones tecnológicas y científicas no implican el desarrollo de nuevos materiales, herramientas matemáticas ni experimentos originales. Son revoluciones conceptuales cuyas consecuencias, impredecibles en principio, acaban transformando toda la sociedad desde su base. Una de las revoluciones conceptuales más importantes de nuestra historia tuvo lugar en algún momento del final de la década de los 80 del siglo XIV.