Erdinc Sezgin

Nov 23, 2024 | nature.com | Sho Oasa |Erdinc Sezgin |Yuelong Ma |David Horne |Mihajlo D. Radmilović |Tijana Jovanović-Talisman | +2 more

AbstractNaltrexone (NTX), a homolog of the opiate antidote naloxone, is an orally active long-acting general opioid receptor antagonist used in the treatment of opiate dependence. NTX is also found to relieve craving for alcohol and is one of few FDA-approved medications for treatment of alcohol use disorder (AUD).

Jan 14, 2024 | nature.com | Linnea Z. Drexhage |Shengpan Zhang |Franziska Ragaller |Ellen Sjule |Lachlan P. Deimel |Helen Robertson | +4 more

AbstractEfferocytic clearance of apoptotic cells in general, and T cells in particular, is required for tissue and immune homeostasis. Transmembrane mucins are extended glycoproteins highly expressed in the cell glycocalyx that function as a barrier to phagocytosis. Whether and how mucins may be regulated during cell death to facilitate efferocytic corpse clearance is not well understood.