Lachlan P. Deimel

Dec 19, 2024 | science.org | Andrew MacLean |Andrew Maclean |Lachlan P. Deimel |Pengcheng Zhou |Mohamed ElTanbouly |Julia Merkenschlager

Published InArticle versionsSubmission historyReceived: 12 July 2024Resubmitted: 8 October 2024Accepted: 28 November 2024AcknowledgmentsWe thank T. Kurosaki for providing S1pr2-CreERT2 mice, T. Eisenreich for mouse colony management, K. Gordon for cell sorting, Anna Minh Newen for INDIA mice immunizations and all members of the Nussenzweig laboratory for helpful discussion.

Nov 29, 2024 | biorxiv.org | Andrew MacLean |Andrew Maclean |Lachlan P. Deimel |Pengcheng Zhou |Mohamed A. ElTanbouly

AbstractIncreased antibody affinity over time after vaccination, known as affinity maturation, is a prototypical feature of immune responses. Recent studies have shown that a diverse collection of B cells, producing antibodies with a wide spectrum of different affinities, are selected into the plasma cell (PC) pathway. How affinity-permissive selection enables PC affinity maturation remains unknown.

Jan 14, 2024 | nature.com | Linnea Z. Drexhage |Shengpan Zhang |Franziska Ragaller |Ellen Sjule |Lachlan P. Deimel |Helen Robertson | +4 more

AbstractEfferocytic clearance of apoptotic cells in general, and T cells in particular, is required for tissue and immune homeostasis. Transmembrane mucins are extended glycoproteins highly expressed in the cell glycocalyx that function as a barrier to phagocytosis. Whether and how mucins may be regulated during cell death to facilitate efferocytic corpse clearance is not well understood.