Eric J. Nestler

Jan 21, 2025 | thetransmitter.org | Omar Abubaker |Karla R Kaun |Eric J. Nestler |Lauren Schenkman

Over the past 20 years, our understanding of the brain and how things can go awry in disease has exploded, driven by advances in our ability to visualize, record and manipulate discrete circuits in the brain; in molecular biology and genetics; and in funding programs, such as the BRAIN Initiative, to bolster brain research. But much of this knowledge has not trickled down to nonscientists.

May 24, 2024 | cell.com | Eric J. Nestler |Scott Russo

Gillespie C.F. Bradley B. Mercer K. Smith A.K. Conneely K. Gapen M. Weiss T. Schwartz A.C. Cubells J.F. Ressler K.J. Trauma exposure and stress-related disorders in inner city primary care patients. Gen. Hosp. Psychiatry. 2009; 31: 505-514https://doi.org/10.1016/j.genhosppsych.2009.05.003The psychobiology of resilience and vulnerability to anxiety disorders: implications for prevention and treatment. Dial. Clin. Neurosci. 2003; 5: 207-221https://doi.org/10.31887/DCNS.2003.5.3/dcharneyComtesse H. Powell S.

Apr 29, 2024 | biologicalpsychiatryjournal.com | Eric J. Nestler

The relative lack of progress in psychiatry compared to other medical disciplines over the past half century reflects the rudimentary experimental approaches available until recently. We now have a range of advanced tools that for the first time enable penetrating studies of the brain. These tools make it possible to understand how a cell’s molecular constituents drive that cell’s functioning within a larger neural circuit, and we are just beginning to decode how circuits generate behaviors.

Feb 7, 2024 | nature.com | Eric J. Nestler

AbstractDNA cytosine methylation has been documented as a potential epigenetic mechanism of transcriptional regulation underlying opioid use disorder. However, methylation of RNA cytosine residues, which would drive another level of biological influence as an epitranscriptomic mechanism of gene and protein regulation has not been studied in the context of addiction.

Feb 7, 2024 | nature.com | Flurin Cathomas |Kenny Chan |Long Li |Lyonna F. Parise |Romain Durand-de Cuttoli |Eric M. Parise | +8 more

AbstractPsychosocial stress has profound effects on the body, including the immune system and the brain1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)3, the underlying mechanisms are not well understood.