Li Shen

Jan 15, 2025 | nature.com | Hongling Zheng |Li Shen |Anke Tang |Yong Luo |Han Hu |Bo Du | +1 more

AbstractFoundation models have demonstrated remarkable performance across various tasks, primarily due to their abilities to comprehend instructions and access extensive, high-quality data. These capabilities showcase the effectiveness of current foundation models and suggest a promising trajectory.

Jan 13, 2025 | peerj.com | Xiaolan Chen |Li Shen |Lee YM |Jurong Ding

A total of 12 six-to-eight-week adult male C57BL/6J mice (18–22 g) were purchased from the Shanghai Model Organisms Center, Inc. and housed in a specific-pathogen-free facility under a light/dark cycle of 12 h/12 h, with access to food and water ad libitum. The mice were housed at a density of five mice per cage to ensure adequate space for activity and optimal housing conditions. No mice were excluded from the analysis.

Jan 8, 2025 | nature.com | Qingfei Zheng |Shuai Zhao |Stephanie Stransky |Giuseppina Di Salvo |Jinghua Wu |Lauren E Vostal | +8 more

AbstractHistone H3 monoaminylations at Gln5 represent an important family of epigenetic marks in brain that have critical roles in permissive gene expression1,2,3. We previously demonstrated that serotonylation4,5,6,7,8,9,10 and dopaminylation9,11,12,13 of Gln5 of histone H3 (H3Q5ser and H3Q5dop, respectively) are catalysed by transglutaminase 2 (TG2), and alter both local and global chromatin states.

Jan 3, 2025 | science.org | Zhen Ma |Ming Li |Rui Guo |Yu Tian |Yongbin Zheng |Bingxin Huang | +13 more

Research ArticleAPPLIED SCIENCES AND ENGINEERINGINTRODUCTIONIschemic heart disease remains a leading cause of mortality and disability worldwide, affecting approximately 126 million people globally (1, 2). Myocardial infarction (MI) is the most severe form of ischemic heart disease (3). Now, adverse ventricular remodeling and heart failure following MI continue to be the primary contributors to patient mortality (4).

Dec 8, 2024 | mdpi.com | Xiang Han |Li Shen |Lixing Yao |Yu Xin Liu

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