Eric Solary

1 month ago | digitalcommons.library.tmc.edu | Joseph Khoury |Eric Solary |Oussama Abla |Yassmine Akkari

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Nov 21, 2024 | nature.com | Vincent Alcazer |Stéphane Depil |Aline Renneville |Dorothée Selimoglu-Buet |Raphael Itzykson |Lucie Laplane | +3 more

AbstractChronic myelomonocytic leukemia (CMML) is a severe myeloid malignancy affecting the elderly, for which therapeutic options are limited. DNA hypomethylating agents (HMAs) provide transient responses, failing to eradicate the malignant clone. Hematopoietic stem cell (HSC) aging involves heterochromatin reorganization, evidenced by alterations in histone marks H3K9me2 and H3K9me3. These repressive marks together with DNA methylation are essential for suppressing transposable elements (TEs).

Apr 7, 2024 | nature.com | Carine D. Lefèvre |Raphaël M. Mangione |Batoul Farhat |Ismael Boussaid |Chloé Friedrich |Aurore Tourville | +21 more

AbstractMyelodysplastic syndromes (MDS) with mutated SF3B1 gene present features including a favourable outcome distinct from MDS with mutations in other splicing factor genes SRSF2 or U2AF1. Molecular bases of these divergences are poorly understood. Here we find that SF3B1-mutated MDS show reduced R-loop formation predominating in gene bodies associated with intron retention reduction, not found in U2AF1- or SRSF2-mutated MDS.

Sep 12, 2023 | embopress.org | Eric Solary

Human CMV, a double-strand DNA virus of the herpes family, is a ubiquitous pathogen that is usually acquired in childhood or early adult life through contact with infected individuals' body fluids. About 70% of the population across the world carry evidence of infection. Primary CMV infection in immunocompetent people is usually asymptomatic or induces mild clinical manifestations. The virus subsequently persists lifelong in a latent form in myeloid cells of the host.

Mar 26, 2023 | nature.com | Andreas Hochhaus |Eric Solary