Erya Wen

Oct 2, 2024 | onlinelibrary.wiley.com | Shenzhen Maternity |Erya Wen |Yang Liu |Caiqun Luo

1 Introduction The prevalence of central nervous system (CNS) abnormalities is 0.14%–0.16% among live births and is as high as 3%–6% among stillbirths (Onkar, Onkar, and Mitra 2014; Sun et al. 2015; Huang et al. 2012). Causes of foetal CNS abnormalities vary. In addition to environmental factors, CNS abnormalities in foetuses are frequently associated with chromosomal aneuploidy, copy number variants (CNVs) and pathogenic sequence variants in developmental genes.