Estefania Sanchez-Vasquez

Jul 22, 2024 | journals.plos.org | Estefania Sanchez-Vasquez |Rocío Márquez |Michael Piacentino |Yanel E. Bernardi

Citation: Bernardi YE, Sanchez-Vasquez E, Márquez RB, Piacentino ML, Urrutia H, Rossi I, et al. (2024) miR-203 secreted in extracellular vesicles mediates the communication between neural crest and placode cells required for trigeminal ganglia formation. PLoS Biol 22(7): e3002074. https://doi.org/10.1371/journal.pbio.3002074Academic Editor: Cody J.

Jul 19, 2024 | biorxiv.org | Estefania Sanchez-Vasquez |Magdalena Zernicka-Goetz |Marianne E. Bronner

AbstractHuman fertility is suboptimal, partly due to error-prone divisions in early cleavage-stages that result in aneuploidy. Most human pre-implantation are mosaics of euploid and aneuploid cells, however, mosaic embryos with a low proportion of aneuploid cells have a similar likelihood of developing to term as fully euploid embryos. How embryos manage aneuploidy during development is poorly understood.

Sep 5, 2023 | biorxiv.org | Estefania Sanchez-Vasquez |Magdalena Zernicka-Goetz |Marianne E. Bronner

AbstractWe previously modeled elimination of aneuploid cells in mouse embryos using the Mps1 inhibitor reversine. Here, we develop an alternative model using AZ3146, a highly specific Mps1 inhibitor, to understand survival of mosaic embryos. AZ3146 treated embryos overexpress Hypoxia-Inducible-Factor-1A(HIF1A), inhibition of which results in a decreased cell number of extra-embryonic trophectoderm but not embryonic epiblast.