Eugene V Koonin

Mar 18, 2024 | biorxiv.org | Mart Krupovic |Jens H. Kuhn |Matthias Fischer |Eugene V Koonin

AbstractThe phylum Preplasmiviricota (kingdom Bamfordvirae, realm Varidnaviria) is a broad assemblage of diverse viruses with comparatively short double-stranded DNA genomes (<50 kbp) that produce icosahedral capsids built from double jelly-roll major capsid proteins. Preplasmiviricots infect hosts from all cellular domains, testifying to their ancient origin and, in particular, are associated with six of the seven supergroups of eukaryotes.

Oct 11, 2023 | nature.com | Eugene V Koonin

NEWS AND VIEWS 11 October 2023 The COVID-19 pandemic highlighted the need to understand the emergence of viral variants, given that these can have implications for vaccination success. A bioinformatics tool offers a way to predict viral evolution. The COVID-19 pandemic, the first epidemic to affect society on a global level since the influenza pandemic in 1918, has put the problem of predicting viral evolution at the forefront of biomedical research.

Aug 27, 2023 | microbiologyresearch.org | Eugene V Koonin |Martin Muller |Paul Schnitzler

Cytoplasmic DNA viruses encode a DNA-dependent RNA polymerase (DdRP) that is essential for transcription of viral genes. The amino acid sequences of known large subunits of DdRPs contain highly conserved regions. Oligonucleotide primers deduced from two conserved domains [RQP(T/S)LH and NADFDG- DE] were used in PCR experiments for the detection of the corresponding gene of the genome of insect iridescent virus type 6 also known as Chilo iridescent virus (CIV).

May 1, 2023 | nature.com | Mart Krupovic |Eugene V Koonin

Cite this articleKrupovic, M., Dolja, V.V. & Koonin, E.V. The virome of the last eukaryotic common ancestor and eukaryogenesis. Nat Microbiol (2023). https://doi.org/10.1038/s41564-023-01378-yDownload citationReceived: 06 November 2022Accepted: 29 March 2023Published: 01 May 2023DOI: https://doi.org/10.1038/s41564-023-01378-yShare this articleAnyone you share the following link with will be able to read this content:Sorry, a shareable link is not currently available for this article.

Apr 10, 2023 | pnas.org | Eugene V Koonin |Zahra A. Aldawood |Luigi Mancinelli |Xuehui Geng

R. L. Tatusov, E. V. Koonin, D. J. Lipman, A genomic perspective on protein families. Science 278, 631–637 (1997). E. V. Koonin, K. S. Makarova, L. Aravind, Horizontal gene transfer in prokaryotes: Quantification and classification. Annu. Rev. Microbiol. 55, 709–742 (2001). K. S. Makarova, Y. I. Wolf, S. L. Mekhedov, B. G. Mirkin, E. V. Koonin, Ancestral paralogs and pseudoparalogs and their role in the emergence of the eukaryotic cell. Nucleic Acids Res. 33, 4626–4638 (2005). M. Lynch, J. S.