Evelyn Lemus Silva

Nov 21, 2023 | biorxiv.org | Matthew R Olm |Sean Paul Spencer |Justin L. Sonnenburg |Evelyn Lemus Silva

AbstractIgA, the most highly produced human antibody, is continually secreted into the gut to shape the intestinal microbiota. Methodological limitations have critically hindered defining which microbial strains are targeted by IgA and why. Here, we develop a new technique, Metagenomic Immunoglobulin Sequencing (MIG-Seq), and use it to determine IgA coating levels for thousands of gut microbiome strains in healthy humans.