Ewa Z. Kulczykowska

Dec 8, 2023 | frontiersin.org | Sun Yat-sen |Nicholas J. Bernier |Hironori Ando |Ewa Z. Kulczykowska

1 IntroductionEstrogens are critical for female reproduction (1). The final and rate limiting step for bioactive estrogen production involves the aromatase (Cyp19a1) enzyme that converts the aromatizable androgens, testosterone and androstenedione, into the bioactive estrogens, estradiol (E2) and estrone, respectively (2).