Ewoud B. Compeer

Jun 10, 2024 | nature.com | Ewoud B. Compeer |Aristides G. Eliopoulos |Themis Alissafi |Michael L. Dustin

AbstractCancer-associated fibroblasts (CAFs) have emerged as a dominant non-hematopoietic cell population in the tumour microenvironment, serving diverse functions in tumour progression. However, the mechanisms via which CAFs influence the anti-tumour immunity remain poorly understood. Here, using multiple tumour models and biopsies from cancer patients, we report that α-SMA+ CAFs can form immunological synapses with Foxp3+ regulatory T cells (Tregs) in tumours.