Fabin Dang

Apr 15, 2024 | nature.com | Fabin Dang |Lin Wang |Wenxue Li |Felipe Batalini |Jaymin Patel |John G. Clohessy | +4 more

AbstractInduced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is known about its regulation after phosphorylation and how to effectively harness APC/CCDH1 activity to treat cancer.

Dec 6, 2023 | science.org | Björn Corleis |Wensen Jiang |Niklas Lang |Fabin Dang

USP2 inhibition prevents infection with ACE2-dependent coronaviruses in vitro and is protective against SARS-CoV-2 in miceFabin Dang https://orcid.org/0000-0002-1954-8231, Lei Bai https://orcid.org/0000-0001-8968-3386, [...] , Jiazhen Dong https://orcid.org/0000-0001-6040-4363, Xiaoping Hu https://orcid.org/0000-0002-7415-2336, [...] , Jingchao Wang https://orcid.org/0009-0005-8026-988X, Joao A.

Dec 6, 2023 | sciencemag.org | Björn Corleis |Wensen Jiang |Niklas Lang |Fabin Dang

Published In Science Translational MedicineVolume 15 | Issue 725December 2023Article versionsSubmission historyReceived: 13 March 2023Accepted: 7 November 2023PermissionsRequest permissions for this article. AcknowledgmentsWe thank all members of the Wei Lab for critical reading and thoughtful comments on the manuscript. Funding: This work is supported by 1K99CA263194 (to F.D.), R35CA253027 (to W.W.), and grants (32188101 and 81930060) from the Natural Science Foundation of China (to K.L.).