Wenxue Li

Apr 15, 2024 | nature.com | Fabin Dang |Lin Wang |Wenxue Li |Felipe Batalini |Jaymin Patel |John G. Clohessy | +4 more

AbstractInduced oncoproteins degradation provides an attractive anti-cancer modality. Activation of anaphase-promoting complex (APC/CCDH1) prevents cell-cycle entry by targeting crucial mitotic proteins for degradation. Phosphorylation of its co-activator CDH1 modulates the E3 ligase activity, but little is known about its regulation after phosphorylation and how to effectively harness APC/CCDH1 activity to treat cancer.

Jan 9, 2024 | pubs.rsc.org | Wenxue Li |Sheng Liu

W. Li and S. Liu, Org. Biomol. Chem., 2024, Accepted Manuscript , DOI: 10.1039/D4OB00033A To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page. If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.