Fabio Parmeggiani

Sep 4, 2023 | nature.com | Neville P. Bethel |Andrew J. Borst |Fabio Parmeggiani |Asim K. Bera |Marcos Miranda |Ryan Kibler | +1 more

AbstractMolecular systems with coincident cyclic and superhelical symmetry axes have considerable advantages for materials design as they can be readily lengthened or shortened by changing the length of the constituent monomers. Among proteins, alpha-helical coiled coils have such symmetric, extendable architectures, but are limited by the relatively fixed geometry and flexibility of the helical protomers.