Andrew J. Borst

May 9, 2024 | nature.com | Erin Yang |Marcos Miranda |Andrew J. Borst |Jason Zhang |Nicolas Goldbach |Maggie Ahlrichs | +5 more

AbstractProgramming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and is important for targeted delivery of biologics. Here we describe the design of octahedral non-porous nanoparticles with a targeting antibody on the two-fold symmetry axis, a designed trimer programmed to disassemble below a tunable pH transition point on the three-fold axis, and a designed tetramer on the four-fold symmetry axis.

Sep 4, 2023 | nature.com | Neville P. Bethel |Andrew J. Borst |Fabio Parmeggiani |Asim K. Bera |Marcos Miranda |Ryan Kibler | +1 more

AbstractMolecular systems with coincident cyclic and superhelical symmetry axes have considerable advantages for materials design as they can be readily lengthened or shortened by changing the length of the constituent monomers. Among proteins, alpha-helical coiled coils have such symmetric, extendable architectures, but are limited by the relatively fixed geometry and flexibility of the helical protomers.