Facultad de Microbiología

May 1, 2024 | academic.oup.com | San Jose |Costa Rica |Instituto Clodomiro Picado |Facultad de Microbiología

Tarantulas are one of the largest predatory arthropods in tropical regions. Tarantulas though not lethal to humans, their venomous bite kills small animals and insect upon which they prey. To understand the abiotic and biotic components involved in Neotropical tarantula bites, we conducted a venom-microbiomics study in eight species from Costa Rica.

Mar 26, 2024 | journals.plos.org | Jose Gutierrez |José María Gutiérrez |Instituto Clodomiro Picado |Facultad de Microbiología |Juliette Borri

Citation: Borri J, Gutiérrez JM, Knudsen C, Habib AG, Goldstein M, Tuttle A (2024) Landscape of toxin-neutralizing therapeutics for snakebite envenoming (2015–2022): Setting the stage for an R&D agenda. PLoS Negl Trop Dis 18(3): e0012052. https://doi.org/10.1371/journal.pntd.0012052Editor: Wuelton M. Monteiro, Fundação de Medicina Tropical Doutor Heitor Vieira Dourado, BRAZILReceived: October 5, 2023; Accepted: March 5, 2024; Published: March 26, 2024Copyright: © 2024 Borri et al.

Aug 16, 2023 | frontiersin.org | Instituto Clodomiro Picado |Facultad de Microbiología |Costa Rica |Departamento de Bioquímica

IntroductionNeutrophils play a critical role in the innate immune response against pathogens through chemokines and cytokines secretion, degranulation, phagocytosis, ROS generation, and the release of NETs (Liew and Kubes, 2019). NETs are filamentous structures of decondensed DNA coated with several proteins with microbicidal activity that trap and kill pathogens, preventing their dissemination (Papayannopoulos, 2018; Schultz et al., 2022).