Departamento de Bioquímica

May 2, 2024 | academic.oup.com | Juan Francisco |Departamento de Bioquímica |Servicio de Microbiología |Juan Antonio

The COVID-19 pandemic highlighted the importance of effective vaccination strategies in controlling the spread of infectious diseases. SARS-CoV-2 vaccine has demonstrated high efficacy in preventing COVID-19 infection in the general population. However, the efficacy of this vaccine in patients with predominantly antibody deficiencies, such as common variable immunodeficiency (CVID) and X-linked agammaglobulinemia (XLA), should be closely monitored.

Oct 30, 2023 | frontiersin.org | Universitat de Barcelona |Departamento de Bioquímica |Facultad de Medicina |Ángel Lanas

Deceased organ donation consists of both donation after circulatory death (CD) and donation after brain death (BD) (1). The majority of liver transplants (~80%) involve organs from BD donors, with 4–20% originating from CD donors (2).

Aug 16, 2023 | frontiersin.org | Instituto Clodomiro Picado |Facultad de Microbiología |Costa Rica |Departamento de Bioquímica

IntroductionNeutrophils play a critical role in the innate immune response against pathogens through chemokines and cytokines secretion, degranulation, phagocytosis, ROS generation, and the release of NETs (Liew and Kubes, 2019). NETs are filamentous structures of decondensed DNA coated with several proteins with microbicidal activity that trap and kill pathogens, preventing their dissemination (Papayannopoulos, 2018; Schultz et al., 2022).

Jun 21, 2023 | frontiersin.org | Facultad de Ciencias |Juan Pablo |Departamento de Bioquímica |Facultad de Medicina

Natalia Rego1,2, María Gabriela Libisch3, Carlos Rovira4†, Juan Pablo Tosar5,6 and Carlos Robello3,7* 1Unidad de Bioinformática, Institut Pasteur de Montevideo, Montevideo, Uruguay 2Laboratorio de Genómica Evolutiva, Facultad de Ciencias, Universidad de la República, Montevideo, Uruguay 3Laboratorio de Interacciones Hospedero Patógeno/UBM, Institut Pasteur de Montevideo, Montevideo, Uruguay 4Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden 5Laboratorio...

May 1, 2023 | frontiersin.org | Facultad de Medicina |Facultad de Ciencias |Ana Paula |Departamento de Bioquímica

IntroductionNeospora caninum is a coccidian parasite of the Apicomplexan phylum, and the causative agent of bovine and canine neosporosis (1). In domestic and wild dogs, neosporosis may be a debilitating neurological disease. In addition, Bovine neosporosis is one of the leading causes of bovine abortion worldwide. Due to the burden on the economy worldwide, neosporosis is known as the billion-dollar disease (2). As part of its obligatory intracellular life cycle, N.