Faith H. Brennan

Jun 12, 2024 | science.org | Faith H. Brennan |Ahmed M Khalaf |Janaki Manoja Vinnakota |Miriam Manook

Editor’s summaryIn organ transplantation, highly sensitized individuals are difficult to match and experience higher rates of antibody-mediated rejection (AMR). Xenotransplantation may therefore be a treatment option for these patients. Here, Manook et al. transplanted kidneys from transgenic pigs into highly sensitized rhesus macaques, finding that recipients showed early graft failure due to AMR despite anti-CD154 monoclonal antibody–based immunosuppression.

Jun 12, 2024 | science.org | Faith H. Brennan |Ahmed M Khalaf |Janaki Manoja Vinnakota |Rachael Adams

Editor’s summaryImmune checkpoint inhibitors targeting PD-1 and CTLA-4 have revolutionized cancer treatment, but these powerful treatments come at a cost. A subset of patients who receive these therapies develop immune-related adverse events (irAEs). These irAEs can affect multiple tissues, including the central nervous system (CNS). Here, Vinnakota et al. studied the CNS after PD-1 blockade in mice with and without tumors.