Miriam Manook

Jan 1, 2025 | science.org | Imran Anwar |Isabel DeLaura |Joseph M. Ladowski |Davide Schilirò |Qimeng Gao |Miriam Manook | +11 more

Research ArticleKIDNEY TRANSPLANTScience Translational Medicine1 Jan 2025Vol 17, Issue 779 Access the full articleView all access options to continue reading this article. Supplementary MaterialsFigs. S1 to S10Tables S1 and S2MDAR Reproducibility ChecklistREFERENCES AND NOTES1G. Muduma, I. Odeyemi, J. Smith-Palmer, R. F. Pollock, Review of the clinical and economic burden of antibody-mediated rejection in renal transplant recipients. Adv. Ther. 33, 345–356 (2016). 2F. K. Port, R. A. Wolfe, E. A. Mauger, D. P.

Jun 12, 2024 | science.org | Faith H. Brennan |Ahmed M Khalaf |Janaki Manoja Vinnakota |Miriam Manook

Editor’s summaryIn organ transplantation, highly sensitized individuals are difficult to match and experience higher rates of antibody-mediated rejection (AMR). Xenotransplantation may therefore be a treatment option for these patients. Here, Manook et al. transplanted kidneys from transgenic pigs into highly sensitized rhesus macaques, finding that recipients showed early graft failure due to AMR despite anti-CD154 monoclonal antibody–based immunosuppression.