Fandi Wu

Jan 15, 2025 | biorxiv.org | Fandi Wu |Yu Zhao |Yang Xiao |Chenchen Qin

AbstractAlpha-beta T cell receptor (alpha-beta TCR) recognition of peptide-major histocompatibility complexes (pMHCs) is a cornerstone of the adaptive immune system. Fast and accurate modeling of TCR-pMHC structures is crucial for understanding TCR recognition of pMHCs at the molecular level, which is essential for the development of TCR-based therapeutics and vaccines.