Chenchen Qin

Jan 15, 2025 | biorxiv.org | Fandi Wu |Yu Zhao |Yang Xiao |Chenchen Qin

AbstractAlpha-beta T cell receptor (alpha-beta TCR) recognition of peptide-major histocompatibility complexes (pMHCs) is a cornerstone of the adaptive immune system. Fast and accurate modeling of TCR-pMHC structures is crucial for understanding TCR recognition of pMHCs at the molecular level, which is essential for the development of TCR-based therapeutics and vaccines.

Jun 28, 2024 | biorxiv.org | Xiao Zhu |Chenchen Qin |Fang Wang |Fan Yang

AbstractThe central dogma serves as a fundamental framework for understanding the flow and expression of genetic information within living organisms, facilitating the connection of diverse biological sequences across molecule types. In this study, we present CD-GPT (Central Dogma Generative Pretrained Transformer), a generative biological foundation model comprising 1 billion parameters, aiming to capture the intricate system-wide molecular interactions in biological systems.

May 23, 2024 | academic.oup.com | Bo Tang |Chenchen Qin

Lymphocyte trafficking via chemokine receptors such as CCR5 and CXCR3 plays a critical role in the pathogenesis of aGVHD. Our previous studies showed that addition of CCR5 or CXCR3 antagonist could only slightly alleviate the development of aGVHD. Given the specificity of T lymphocytes bearing CXCR3 and CCR5, we investigated whether combined CCR5 and CXCR3 blockade could further attenuate murine aGVHD.