Fangfang Zhou

May 16, 2024 | nature.com | Fangfang Zhou |Long Zhang

DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co-condensation. The co-condensates apply mechanical forces to hold the DNA ends together and generate enzymatic activity for the synthesis of PAR. PARylation can promote the release of PARP1 from DNA ends and recruit various proteins, such as Fused in sarcoma (FUS) proteins, thereby stabilizing broken DNA ends and preventing their separation.

Apr 17, 2024 | journals.plos.org | Shuzhen Zhang |Zhejiang Province |Yixin Chen |Fangfang Zhou

Loading metrics Open Access Peer-reviewedResearch Article Citation: Zhang S, Chen Y, Zhou F, Wang L, Luo Q (2024) Effect of care bundles for acute kidney injury: A systematic review and meta-analysis. PLoS ONE 19(4): e0302179. https://doi.org/10.1371/journal.pone.0302179Editor: Chiara Lazzeri, Azienda Ospedaliero Universitaria Careggi, ITALYReceived: March 10, 2023; Accepted: March 28, 2024; Published: April 17, 2024Copyright: © 2024 Zhang et al.

Jan 3, 2024 | nature.com | Xin He |Fangfang Zhou

AbstractViruses, as opportunistic intracellular parasites, hijack the cellular machinery of host cells to support their survival and propagation. Numerous viral proteins are subjected to host-mediated post-translational modifications. Here, we demonstrate that the SARS-CoV-2 nucleocapsid protein (SARS2-NP) is SUMOylated on the lysine 65 residue, which efficiently mediates SARS2-NP’s ability in homo-oligomerization, RNA association, liquid-liquid phase separation (LLPS).

May 21, 2023 | nature.com | Fangfang Zhou

Dear Editor,Overwhelming evidence suggests that age itself is a prominent risk factor for COVID-19 morbidity and mortality.1,2 However, the molecular basis of aging’s effect on SARS-CoV-2 susceptibility and COVID-19 severity in adults is still not fully understood. Thus, we hypothesized that aging-related cellular landscape alterations influence clinical manifestations, which is critical for determining likely intervention targets to slow the transmission of COVID-19 and reduce severe symptoms.

Mar 27, 2023 | nature.com | Fangfang Zhou |Long Zhang

In a recent study published in Cell, Yang et al. revealed that changes in epigenetic landscapes caused by faithful DNA repair are key drivers accelerating aging of mammalian organs or tissues.1 Impressively, changes in H3K27ac landscape during aging process influence cell identity maintenance, and this aging process can be reversed by the inducible expression of pioneer transcription factors, Oct4, Sox2, and Klf4 (OSK) in the living mammals.