-
3 weeks ago | 
nature.com | Xiaokang Zhang |Long Zhang |Shan Wu
AbstractThe Ebola and the Marburg viruses belong to the Filoviridae family, a group of filamentous, single-stranded, negative-sensed RNA viruses. Upon infection, uncontrolled propagation of the Ebola and the Marburg viruses causes severe hemorrhagic fevers with high mortality rates. The replication and transcription of viral genomes are mediated by a polymerase complex consisting of two proteins: L and its cofactor VP35.
-
Jan 9, 2025 | 
nature.com | Long Zhang
AbstractA switching active disturbance rejection control (SADRC) strategy was proposed to solve the composite disturbance challenge arising from gap, LuGre friction, hydraulic spring force, and external load disturbance in the double closed-loop digital hydraulic cylinder position control system. Firstly, leveraging the established mathematical model of the double closed-loop digital hydraulic cylinder, the high-order state equation was derived.
-
Jan 8, 2025 | 
nature.com | Huang Wu |Yu Wang |Surojit Bhunia |Aspen X.-Y. Chen |Liang Feng |Long Zhang | +4 more
AbstractMimicking the superstructures and properties of spherical biological encapsulants such as viral capsids1 and ferritin2 offers viable pathways to understand their chiral assemblies and functional roles in living systems. However, stereospecific assembly of artificial polyhedra with mechanical properties and guest-binding attributes akin to biological encapsulants remains a formidable challenge.
-
Jan 7, 2025 | 
nature.com | Feng Xie |Long Zhang
AbstractThe mucosal immune system, as the most extensive peripheral immune network, serves as the frontline defense against a myriad of microbial and dietary antigens. It is crucial in preventing pathogen invasion and establishing immune tolerance. A comprehensive understanding of mucosal immunity is essential for developing treatments that can effectively target diseases at their entry points, thereby minimizing the overall impact on the body.
-
Sep 29, 2024 | 
nature.com | Long Zhang
In a recent paper published in Cell,1 Luo and colleagues performed a multi-omics analysis of a prospective phase II clinical trial and elucidated the effector regulatory T cells (eTregs) as novel immunotarget for ovarian cancer with homologous recombination deficiency (HRD), analyzing for the first time at the clinical level how poly (ADP-ribose) polymerase (PARP) inhibitors reshape the ovarian cancer microenvironment.
-
May 16, 2024 | 
nature.com | Fangfang Zhou |Long Zhang
DNA double-strand break (DSB) sites that prevent the disjunction of broken DNA ends are formed through poly (ADP-ribose) (PAR) polymerase 1 (PARP1)-DNA co-condensation. The co-condensates apply mechanical forces to hold the DNA ends together and generate enzymatic activity for the synthesis of PAR. PARylation can promote the release of PARP1 from DNA ends and recruit various proteins, such as Fused in sarcoma (FUS) proteins, thereby stabilizing broken DNA ends and preventing their separation.
-
Feb 16, 2024 | 
pubs.acs.org | Guang-Da Xia |Long Zhang |Yi Wei |Xiao-Qiang Hu
CCDC 2333245 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge via www.ccdc.cam.ac.uk/data_request/cif, or by emailing [email protected], or by contacting The Cambridge Crystallographic Data Centre, 12 Union Road, Cambridge CB2 1EZ, UK; fax: +44 1223 336033. Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions.
-
Feb 12, 2024 | 
mdpi.com | Yiqing Xu |Jiaming Li |Long Zhang |Hongying Liu
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
-
Jan 3, 2024 | 
nature.com | Bin Zhao |Long Zhang |Xin-Hua Feng
AbstractThe Hippo pathway has important roles in organ development, tissue homeostasis and tumour growth. Its downstream effector TAZ is a transcriptional coactivator that promotes target gene expression through the formation of biomolecular condensates. However, the mechanisms that regulate the biophysical properties of TAZ condensates to enable Hippo signalling are not well understood.
-
Oct 15, 2023 | 
nature.com | Zhengyu Gao |Long Zhang
Recently, a study published in Science by Liu et al.1 presented compelling evidence demonstrating that upon translocation to the Golgi apparatus, STING (Stimulator of Interferon Genes) serves as a direct mediator for proton release into the cytosol, thereby instigating non-canonical LC3B (light-chain 3B) lipidation and NLRP3 (NOD-like receptor family pyrin domain–containing 3) inflammasome activation (Fig. 1).
