Fangming Xie

Oct 17, 2024 | biorxiv.org | Fangming Xie |Saumya Jain |Runzhe Xu |Salwan Butrus

AbstractHow early sensory experience during "critical periods" of postnatal life affects the organization of the mammalian neocortex at the resolution of neuronal cell types is poorly understood. We previously reported that the functional and molecular profiles of layer 2/3 (L2/3) cell types in the primary visual cortex (V1) are vision-dependent (Tan et al., Neuron, 108(4), 2020; Cheng et al., Cell, 185(2), 2022).

Dec 18, 2023 | biorxiv.org | Fangming Xie |Saumya Jain |Salwan Butrus |Karthik Shekhar

AbstractWe previously reported that vision specifies Layer 2/3 (L2/3) glutamatergic cell-type identity in the primary visual cortex (V1). Using unsupervised clustering of single-nucleus RNA-sequencing data, we identified molecularly distinct L2/3 cell types in normal-reared (NR) and dark-reared (DR) mice, but the two sets exhibited poor correspondence.