Karthik Shekhar

1 week ago | cell.com | Dario Tommasini |Takeshi Yoshimatsu |Teresa Puthussery |Tom Baden |Karthik Shekhar

1Helen Wills Neuroscience Institute, University of California, Berkeley, Berkeley, CA 94720, USA 2Department of Ophthalmology and Visual Sciences, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA 3Vision Sciences Graduate Group, University of California, Berkeley, Berkeley, CA 94720, USA 4Herbert Wertheim School of Optometry and Vision Science, University of California, Berkeley, Berkeley, CA 94720, USA 5Center for Sensory Neuroscience and Computation, Sussex...

Nov 6, 2024 | biorxiv.org | Dario Tommasini |Takeshi Yoshimatsu |Tom Baden |Karthik Shekhar

AbstractThe tetrapod double cone is a pair of tightly associated cones called the "principal" and the "accessory" member. It is found in amphibians, reptiles, and birds, as well as monotreme and marsupial mammals but is absent in fish and eutherian mammals. To explore the potential evolutionary origins of the double cone, we analyzed single-cell and -nucleus transcriptomic atlases of photoreceptors from six vertebrate species: zebrafish, chicken, lizard, opossum, ground squirrel, and human.

Oct 7, 2024 | biorxiv.org | Salwan Butrus |Christopher Yoo |Daniel Feldman |Karthik Shekhar

AbstractMouse whisker somatosensory cortex (wS1) is a major model system to study the experience-dependent plasticity of cortical neuron physiology, morphology, and sensory coding. However, the role of sensory experience in regulating neuronal cell type development and gene expression in wS1 remains poorly understood.

Dec 18, 2023 | biorxiv.org | Fangming Xie |Saumya Jain |Salwan Butrus |Karthik Shekhar

AbstractWe previously reported that vision specifies Layer 2/3 (L2/3) glutamatergic cell-type identity in the primary visual cortex (V1). Using unsupervised clustering of single-nucleus RNA-sequencing data, we identified molecularly distinct L2/3 cell types in normal-reared (NR) and dark-reared (DR) mice, but the two sets exhibited poor correspondence.

Dec 13, 2023 | nature.com | Karthik Shekhar