Farheen Fatma

Oct 7, 2024 | nature.com | Hannah Brenton |Gaya K. Amarasinghe |Meagan Blanchard |Farheen Fatma

AbstractStaphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an essential virulence factor in disease, impairing the T cell response to infection. The anti-Hla antibody response is a correlate of human protective immunity. Here we observe that this response is limited early in human life and design a vaccine strategy to elicit immune protection against Hla in a neonatal mice.