Gaya K. Amarasinghe

1 month ago | nature.com | Jian Xu |Jay C. Nix |Michael Gross |Steven Brody |Gaya K. Amarasinghe |Jacqueline E. Payton

AbstractThe Mediator complex facilitates interactions between transcription factors and RNA polymerase II, a process that is required for host gene transcription, including in response to viral infections. Among the many subunits in the Mediator complex, the MED25 subunit has been shown to be a target for viral activators during infection.

Oct 7, 2024 | nature.com | Hannah Brenton |Gaya K. Amarasinghe |Meagan Blanchard |Farheen Fatma

AbstractStaphylococcus aureus remains a leading global cause of bacterial infection-associated mortality and has eluded prior vaccine development efforts. S. aureus α-toxin (Hla) is an essential virulence factor in disease, impairing the T cell response to infection. The anti-Hla antibody response is a correlate of human protective immunity. Here we observe that this response is limited early in human life and design a vaccine strategy to elicit immune protection against Hla in a neonatal mice.