Fei Wang

1 month ago | nature.com | Weishen Pan |Zhenxing Xu |Qiannan Zhang |Ying Li |Fei Wang |Deep Hathi

Predicting treatment response is an important problem in real-world applications, where the heterogeneity of the treatment response remains a significant challenge in practice. Unsupervised machine learning methods have been proposed to address this challenge by clustering patients with similar electronic health record (EHR) data. However, they cannot guarantee coherent outcomes within the groups. Here, we propose Graph-Encoded Mixture Survival (GEMS) as a general machine learning framework to identify distinct predictive subphenotypes that guarantee coherent survival and baseline characteristics within each subphenotype. We apply our method to a real-world dataset of advanced non-small cell lung cancer (aNSCLC) patients receiving first-line immune checkpoint inhibitor (ICI) therapy to predict overall survival (OS). Our method outperforms baseline methods for predicting OS and identifies three reproducible subphenotypes associated with distinct baseline clinical characteristics and OS. Our results demonstrate that our method can provide insights in the heterogeneity of treatment response and potentially influence treatment selection. Response to cancer therapeutics is heterogenous making it hard predict despite advances in machine learning approaches. Here, the authors develop a graph neural network-based approach, Graph-Encoded Mixture Survival (GEMS), to identify ‘predictive subphenotypes’ of patients with similar baseline characteristics and survival outcomes of cancer patients using electronic health records to predict patient response to therapy.

1 month ago | dx.doi.org | Fei Wang |Kenneth W. Foreman |Lee A Solomon |Robert F. Spaine

IntroductionClick to copy section linkSection link copied!SN2 reactions involve nucleophilic substitutions in which the reaction rate is first order in each of the nucleophile and substrate. By implication, both species are present in the rate-limiting step. This step corresponds to a single transition state with no intermediates forming between reactant and product states.

Mar 17, 2025 | mdpi.com | Fei Wang |Jingxia Gao |Hui Li |Junle Zhang

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Jan 21, 2025 | mdpi.com | Xing Liu |Yanan Cheng |Ying Zhang |Fei Wang

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.

Jan 8, 2025 | mdpi.com | Fei Wang |Lili Han |Lulu Liu |Yang Wei

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.