Fengyun Shen

Mar 24, 2023 | onlinelibrary.wiley.com | Fengyun Shen |Zijian Xiong |Yumin Wu |Rui Peng

Graphical Abstract Framework nucleic acids (FNAs)-based peptide vaccines with different structures and sizes were constructed to understand the effect of peptide spacing and carrier rigidity on B cell activation, and reveal the significance of precise peptide organization. Epitopes from SARS-CoV-2 were assembled on the preferred FNA to construct a COVID-19 peptide vaccine prototype which effectively triggered humoral immune responses in mice.