Florian J. Fintelmann

Aug 26, 2024 | nature.com | Meghan J. Mooradian |Florian J. Fintelmann |Thomas LaSalle |Alexander Graur |Sophia Z. Shalhout |Howard L. Kaufman | +4 more

AbstractImage-guided percutaneous cryoablation is an established minimally invasive oncologic treatment. We hypothesized that cryoablation may modify the immune microenvironment through direct modulation of the tumor, thereby generating an anti-tumor response in tumors refractory to immune checkpoint inhibition (ICI).

Jun 7, 2024 | arxiv.org | Daniel Rueckert |Florian J. Fintelmann |Philip Müller |Michelle Espranita

Mar 28, 2024 | chestmed.theclinics.com | Alexander Graur |Florian J. Fintelmann

Keywords Thoracic imaging and intervention Lung needle biopsy Lung ablation Cryoablation Microwave ablation To read this article in full you will need to make a payment Academic & Personal: 24 hour online accessCorporate R&D Professionals: 24 hour online access One-time access price info For academic or personal research use, select 'Academic and Personal' For corporate R&D use, select 'Corporate R&D Professionals' Subscribers receive full online access to your subscription and archive of...

Mar 11, 2024 | onlinelibrary.wiley.com | Eric J. Roeland |Florian J. Fintelmann |Fiona Hilton |Ruoyong Yang

Introduction Cancer cachexia is a multifactorial syndrome frequently characterised by anorexia, unintentional weight loss (including skeletal muscle loss), fatigue, functional impairment, poor quality of life, and worse survival.1-3 The pathogenesis of cancer cachexia is under investigation and involves abnormal metabolism and weight loss that cannot be fully reversed with nutritional supplementation.2, 4 Cachexia is frequently observed across various cancers,5 and its management is...

Oct 30, 2023 | nature.com | Florian J. Fintelmann

AbstractA validated open-source deep-learning algorithm called Sybil can accurately predict long-term lung cancer risk from a single low-dose chest computed tomography (LDCT). However, Sybil was trained on a majority-male cohort. Use of artificial intelligence algorithms trained on imbalanced cohorts may lead to inequitable outcomes in real-world settings. We aimed to study whether Sybil predicts lung cancer risk equally regardless of sex.