Franca Fraternali

Dec 20, 2024 | science.org | Justin Joachim |Davide Maselli |Jurjan Aman |Pamela Swiatlowska |David Killock |Hiba Chaudhry | +10 more

MATERIALS AND METHODS Anti–p-ERM/anti–p-Dmoesin (Cell Signaling Technology, 3141), anti-GST (ChromoTek, 6G9), anti–p-Thr (Cell Signaling Technology, 9381), anti-GFP for Western blotting (ChromoTek, 3H9), anti-GFP for immunofluorescence detection of YFP-TNIK (Roche, 11814460001), anti-TNIK (Santa Cruz Biotechnology, sc-136103), anti-Actin (Sigma-Aldrich, A2228), anti–p-MLC2 Ser19 (Cell Signaling Technology, 3671), anti-Ezrin (Cell Signaling Technology, 3145), anti-moesin (Cell Signaling...

Nov 23, 2024 | cell.com | Tom Rees |Rebeca Jimeno |Nikolaos Angelis |Joseph Ng |Franca Fraternali |Vivian Li | +2 more

KeywordsNKT cellintestinal epithelial cellintestinal organoidsIFN-γResearch topic(s)CP: ImmunologyIntroductionThe intestinal epithelium performs key functions in nutrient absorption as well as acts as a barrier to preserve the compartmentalization of the intestinal microbiota. The intestinal lining consists of a monolayer of intestinal epithelial cells (IECs) that is characterized by tight regulation and large turnover capacity.