Francesco Cavallieri

Feb 27, 2023 | mdpi.com | Francesco Cavallieri |Thiago Guimarães |Valentina Fioravanti |Rubens G. Cury

Abstract:Parkinson’s disease (PD) is a multifarious neurodegenerative disease. Its pathology is characterized by a prominent early death of dopaminergic neurons in the pars compacta of the substantia nigra and the presence of Lewy bodies with aggregated α-synuclein. Although the α-synuclein pathological aggregation and propagation, induced by several factors, is considered one of the most relevant hypotheses, PD pathogenesis is still a matter of debate.