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Dec 6, 2024 | 
onlinelibrary.wiley.com | Francis Crick
From refinements of numerous structures while testing the updated CCP4 monomer library, we present a few example cases to demonstrate the improvement in refinement stability and structure model quality. The structures shown in this section were re-refined using Servalcat employing the updated monomer library and restraints based on MetalCoord analysis.
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Sep 5, 2024 | 
kantti.net | Francis Crick
摘要 本文將帶您了解如何選擇最適合的社群行銷公司，以協助企業在競爭激烈的市場中脫穎而出。 歸納要點: 社群行銷公司比較:透過數據分析找到最適合的合作夥伴,了解不同公司的服務內容與技術優勢。 深入探討社群行銷核心技術,包括數據分析、內容策略及KOL合作,揭示提升品牌影響力的方法。 評估社群行銷公司的六大關鍵指標,如團隊經驗和成功案例,幫助企業做出明智的選擇。 掌握正確的選擇與談判策略，可以讓您的品牌在社群媒體上實現更大的影響力。 社群行銷公司大比拼：找到你的最佳拍檔 選擇社群行銷公司時，資料驅動的決策至關重要。現代的行銷專家不僅要追蹤各種社群指標，還要懂得如何把這些資料轉化為實際可行的策略。你可能會想問，怎麼知道哪家公司能做到這一點呢？看看他們是否使用 AI 工具來分析競爭對手和目標受眾的行為，並提供詳細的資料分析報告。 多元平台策略也是不可忽視的一環。在當今多樣化的社群媒體中，只依賴某一個平台已經無法滿足需求。優秀的公司會根據品牌特性制定跨平台策略，例如同時在 Facebook、Instagram 和 TikTok 上運作，以達到最佳效果。 不可或缺的是創新 內容行銷...
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Aug 20, 2024 | 
academic.oup.com | Francis Crick
Modern RNA-coded peptide synthesis is complicated, including the ribosome and various translation factors to enable peptidyl transfer at the (N-acyl-)aminoacylated 3′-CCA termini of two juxtaposed tRNAs (1). Although the details of this mechanism have been elucidated in recent years (2,3), it is not known how translation could have first emerged. According to the RNA world hypothesis (4), first posited in 1986, self-replicating RNA molecules proliferated before the evolution of DNA and proteins.
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Jun 10, 2024 | 
pubs.rsc.org | Jianfeng Xu |Francis Crick
Prebiotic synthesis of dihydrouridine by photoreduction of uridine in formamide†
In this report, we show that a very common modification (especially in tRNA), dihydrouridine, was efficiently produced by photoreduction of the canonical pyrimidine ribonucleoside, uridine in formamide. Formamide not only acts as a solvent in this reaction, but also as the reductant.
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May 30, 2024 | 
pubs.rsc.org | Ziwei Liu |Francis Crick |Downing Street
Manganese(ii) promotes prebiotically plausible non-enzymatic RNA ligation reactions†
Using different prebiotically plausible activating reagents, the RNA ligation yield was significantly increased in the presence of Mn(II). The mechanism of the activation reaction has been investigated using 5′-AMP as an analogue.
This article is Open Access
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Mar 26, 2024 | 
academic.oup.com | Francis Crick
In 2016, Nucleic Acids Research (‘NAR’) assembled a special collection of studies, published in its pages over the preceding five-years, that described the biology and use of CRISPR/Cas systems (1). The 79 manuscripts presented in that collection included 37 studies that described the evolution, genetics, and mechanisms of CRISPR defense systems and an almost equal number of studies describing their development and application for gene modification and genome engineering.
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Jan 31, 2024 | 00011-4&sz=64)
cell.com | Junjie Xu |Simon Erlendsson |Francis Crick |Manvendra Singh
Rosenfeld M.R. Eichen J.G. Wade D.F. Posner J.B. Dalmau J. Molecular and clinical diversity in paraneoplastic immunity to Ma proteins. Ann. Neurol. 2001; 50: 339-348Dalmau J. Gultekin S.H. Voltz R. Hoard R. DesChamps T. Balmaceda C. Batchelor T. Gerstner E. Eichen J. Frennier J. et al. Ma1, a novel neuron- and testis-specific protein, is recognized by the serum of patients with paraneoplastic neurological disorders. Brain. 1999; 122: 27-39Voltz R. Gultekin S.H. Rosenfeld M.R. Gerstner E. Eichen J.
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Jan 4, 2024 | 
academic.oup.com | Francis Crick
This month marks the 50th anniversary of Nucleic Acids Research (‘NAR’). Led by a team of three founding editors (Richard T. Walker and A. Stanley Jones at the University of Birmingham in the UK and Dieter Söll at Yale University in the USA), the journal was formed for the publication of ‘original papers dealing with the physical, chemical, biochemical, biological or medical properties of nucleic acids, their constituents and analogs’ (1).
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Dec 21, 2023 | 
onlinelibrary.wiley.com | Francis Crick |Crown Street
For structural biology practitioners a number of techniques, such as X-ray/neutron/electron crystallography and cryo electron microscopy (cryo-EM), are available to determine the 3D atomic structure of a macromolecular structure. Any one of these techniques can be applied to produce an initial model, comprising atomic positions and their associated uncertainties, which is fitted to the experimental data, such as a set of diffraction intensities or an electrostatic potential map.
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Nov 3, 2023 | 
onlinelibrary.wiley.com | Francis Crick
2.3.2. Reference structure restraints Neutron macromolecular crystallographic data often suffer from limited completeness and high resolution is not always achievable. Therefore, a useful strategy to increase the data-to-parameter ratio in refinement is that of joint neutron/X-ray refinement, provided that an isomorphous X-ray data set is available.
