Francisco Lopera

Nov 28, 2024 | cell.com | Guoqiang Sun |Cheng Wang |Randall C Mazzarino |Hayk Davtyan |Mathew Blurton-Jones |Francisco Lopera | +3 more

Keywordsinduced pluripotent stem cellsiPSCsAPOE Christchurchlipid dropletlipid peroxidationferroptosisphagocytosismicrogliabrain organoidsTaupresenilinresilienceResearch topic(s)CP: NeuroscienceIntroductionAlzheimer’s disease (AD) is a devastating neurodegenerative disease.1,2 However, there is little progress toward therapeutic development for AD.

Nov 17, 2024 | nature.com | Stephan A. Kaeser |Christian la Fougère |Jonathan Voglein |Johannes Levin |Nick Fox |Henrik Zetterberg | +16 more

AbstractDisease-modifying therapies for Alzheimer’s disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, with neurofilament light chain protein (NfL) showing promise for monitoring neurodegeneration and predicting cognitive outcomes.

Nov 17, 2024 | nature.com | Stephan A. Kaeser |Christian la Fougère |Jonathan Voglein |Johannes Levin |Nick Fox |Henrik Zetterberg | +16 more

AbstractDisease-modifying therapies for Alzheimer’s disease (AD) are likely to be most beneficial when initiated in the presymptomatic phase. To track the benefit of such interventions, fluid biomarkers are of great importance, with neurofilament light chain protein (NfL) showing promise for monitoring neurodegeneration and predicting cognitive outcomes.

May 15, 2023 | inkl.com | Francisco Lopera

According to the study, a series of tests and analyses revealed a new genetic variant (differences in DNA between people) that provides protection from the disease. The variant occurs in a different gene than in a case from the same family reported in 2019, but points to a common disease pathway, the study suggests.