Guoqiang Sun

Jan 8, 2025 | nature.com | Guoqiang Sun

AbstractBrain organoid models have greatly facilitated our understanding of human brain development and disease. However, key brain cell types, such as microglia, are lacking in most brain organoid models. Because microglia have been shown to play important roles in brain development and pathologies, attempts have been made to add microglia to brain organoids through co-culture.

Nov 28, 2024 | cell.com | Guoqiang Sun |Cheng Wang |Randall C Mazzarino |Hayk Davtyan |Mathew Blurton-Jones |Francisco Lopera | +3 more

Keywordsinduced pluripotent stem cellsiPSCsAPOE Christchurchlipid dropletlipid peroxidationferroptosisphagocytosismicrogliabrain organoidsTaupresenilinresilienceResearch topic(s)CP: NeuroscienceIntroductionAlzheimer’s disease (AD) is a devastating neurodegenerative disease.1,2 However, there is little progress toward therapeutic development for AD.