Francisco Martínez-Peña

Nov 17, 2023 | cell.com | Petra den Hollander |Maria Lourdes Castaneda |Maria Jose Castañeda |María Julia Castañeda |Francisco Martínez-Peña |Nick A. Kuburich

Highlights • Stabilizing vimentin phosphorylation at serine 56 causes multinucleation in hybrid E/M cells • Cancer stem-like cells (CSCs) preferentially become multinucleated after stabilizing vimentin phosphorylation • Multinucleated CSCs lead to a loss of stemness properties due to reduced self-renewal • Stabilizing vimentin phosphorylation at serine 56 inhibits metastasis Summary Epithelial-mesenchymal transition (EMT) empowers epithelial cells with mesenchymal and stem-like attributes,...