
Petra den Hollander
Articles
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2 months ago |
mdpi.com | Maria Lourdes Castaneda |Maria Dolores Castañeda |María Montesinos Castañeda |Petra den Hollander |Steve Werden |Esmeralda Ramirez-Peña
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Nov 17, 2023 |
cell.com | Petra den Hollander |Maria Lourdes Castaneda |Maria Jose Castañeda |María Julia Castañeda |Francisco Martínez-Peña |Nick A. Kuburich
Highlights • Stabilizing vimentin phosphorylation at serine 56 causes multinucleation in hybrid E/M cells • Cancer stem-like cells (CSCs) preferentially become multinucleated after stabilizing vimentin phosphorylation • Multinucleated CSCs lead to a loss of stemness properties due to reduced self-renewal • Stabilizing vimentin phosphorylation at serine 56 inhibits metastasis Summary Epithelial-mesenchymal transition (EMT) empowers epithelial cells with mesenchymal and stem-like attributes,...
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