François-René Bertin

Sep 18, 2024 | onlinelibrary.wiley.com | Kate Kemp |François-René Bertin

AUC area under the curve BCS body condition score CNS cresty neck score EMS Equine Metabolic Syndrome HI-IR hyperinsulinemic and insulin-resistant HI-NIR hyperinsulinemic and noninsulin-resistant ID insulin dysregulation IR insulin-resistant mFSIGTT modified frequently sampled IV glucose tolerance test NEFA nonesterified fatty acid OGT oral glucose test 1 INTRODUCTION Insulin dysregulation (ID) manifests as either hyperinsulinemia (resting or in response to a carbohydrate challenge), tissue...

Jul 29, 2024 | digitalcommons.library.tmc.edu | Darko Stefanovski |Mary Robinson |Kate Kemp |François-René Bertin

BACKGROUND: Sirolimus, a mechanistic target of rapamycin inhibitor, suppresses insulin production in other species and has therapeutic potential for hyperinsulinemia in horses. HYPOTHESIS/OBJECTIVE: Determine the pharmacokinetics (PKs) of sirolimus and evaluate its effect on insulin dynamics in healthy and insulin dysregulation (ID) horses. ANIMALS: Eight Standardbred geldings. METHODS: A PK study was performed followed by a placebo-controlled, randomized, crossover study.