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Dec 4, 2024 | 
beva.onlinelibrary.wiley.com | Claire Solomon |Mary M. Durando |Darko Stefanovski
1 INTRODUCTION Exercising arrhythmias occur frequently in horses participating in all equestrian disciplines.1-7 In most instances exercising arrhythmias occur in the absence of clinical signs and are common in horses without signs of cardiac disease.1-3, 6, 7 The association between arrhythmias and performance is unclear, and many successful horses display arrhythmias during and after exercise.6, 8 The intensity of the exercise, often estimated by the peak heart rate during exercise, has...
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Nov 20, 2024 | 
beva.onlinelibrary.wiley.com | Elizabeth Acutt |Darko Stefanovski |Andrew van Eps |Georgia Skelton
AUC area under the curve DHW dorsal hoof wall DP dorsopalmar EL endocrinopathic laminitis IHW inner hoof wall LHW lateral hoof wall LLZ lamellar lucent zone LM lateromedial MHW medial hoof wall OHW outer hoof wall PCL palmar cortex length Pd distal phalanx, coffin bone PEL primary epidermal lamellae ROC receiver operator curve Sole LZ sole lucent zone SRL sepsis related laminitis 1 INTRODUCTION The diagnosis of acute laminitis is based on clinical signs that include multi-limb lameness,...
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Oct 18, 2024 | 
mdpi.com | Nadine Nagy |Kathryn S. Czepiel |Gernot Kaber |Darko Stefanovski
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
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Jul 29, 2024 | 
digitalcommons.library.tmc.edu | Darko Stefanovski |Mary Robinson |Andrew van Eps |Van Eps
BACKGROUND: Insulin dysregulation (ID) is the most important risk factor for the development of laminitis in horses and therapies to control it are needed. HYPOTHESIS/OBJECTIVES: To assess the effects of a single dose of the synthetic GLP-1 analog exenatide on postprandial insulin dynamics. We hypothesized that exenatide would improve insulin sensitivity and lower postprandial blood insulin concentrations. STUDY DESIGN: Randomized, crossover, experimental study.
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Jul 29, 2024 | 
digitalcommons.library.tmc.edu | Darko Stefanovski |Mary Robinson |Kate Kemp |François-René Bertin
BACKGROUND: Sirolimus, a mechanistic target of rapamycin inhibitor, suppresses insulin production in other species and has therapeutic potential for hyperinsulinemia in horses. HYPOTHESIS/OBJECTIVE: Determine the pharmacokinetics (PKs) of sirolimus and evaluate its effect on insulin dynamics in healthy and insulin dysregulation (ID) horses. ANIMALS: Eight Standardbred geldings. METHODS: A PK study was performed followed by a placebo-controlled, randomized, crossover study.
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Jul 26, 2024 | 
digitalcommons.library.tmc.edu | Megan Palmisano |Jeaneen Kulp |Susan Bender |Darko Stefanovski
BACKGROUND: Eight-hydroxy-2'-deoxyguanosine (8-OHdG), a biomarker of oxidative damage evaluated in human neurodegenerative disease, has potential to correlate with postmortem diagnosis of neuroaxonal dystrophy/degenerative myeloencephalopathy (NAD/DM) in horses. HYPOTHESIS: We hypothesized that 8-OHdG will be higher in CSF and serum from NAD/DM horses compared with horses with other neurologic diseases (CVSM, EPM) and a control group of neurologically normal horses.
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Jul 18, 2024 | 
onlinelibrary.wiley.com | Bridget Lyons |Darko Stefanovski |Deborah C. Silverstein |Mallory V. Horridge
Objectives To develop a novel illness severity scoring system to identify canine patients with infection that are at higher risk of mortality. Key Findings Mentation (Modified Glasgow Coma Scale and the Acute Patient Physiologic and Laboratory Evaluation mentation score), heart rate, pH, Pvco2, potassium, and total plasma protein were found to be associated with mortality on univariate analysis.
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Jul 11, 2024 | 
beva.onlinelibrary.wiley.com | Elizabeth Davidson |Darko Stefanovski |Joann Slack |Timothy J. Manzi
1 INTRODUCTION Cervical articular process joint (CAPJ) therapy is advocated for horses with abnormal clinical signs associated with neck disorders. In a retrospective study,1 71% of horses with ataxia, obscure lameness, or neck pain improved or returned to normal function following treatment with ultrasound-guided CAPJ corticosteroid injections.
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Jan 11, 2024 | 
onlinelibrary.wiley.com | Megan Palmisano |Susan Bender |Darko Stefanovski |Jeaneen Kulp
3-NT 3-nitrotyrosine 4HNE 4-hydroxynonenal 8-OHdG 8-hydroxy-2′-deoxyguanosine CNS central nervous system CSF cerebrospinal fluid DM degenerative myeloencephalopathy NAD neuroaxonal dystrophy F2 isoP F2-isoprostane PBS phosphate-buffered saline ROS reactive oxygen species 1 INTRODUCTION The neurodegenerative disease termed neuroaxonal dystrophy (NAD)/degenerative myeloencephalopathy (DM) has become increasingly recognized as a cause of neurologic disease in horses. Diagnosis is based on...
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Dec 11, 2023 | 
mdpi.com | Jun Yang |Darko Stefanovski |Bruce D. Hammock |Jang H. Youn
All articles published by MDPI are made immediately available worldwide under an open access license. No specialpermission is required to reuse all or part of the article published by MDPI, including figures and tables. Forarticles published under an open access Creative Common CC BY license, any part of the article may be reused withoutpermission provided that the original article is clearly cited. For more information, please refer tohttps://www.mdpi.com/openaccess.
