Frank Schnütgen

May 28, 2024 | mdpi.com | Frank Schnütgen |Ralf Kühn |Seren Sevim-Wunderlich |Jana Rossius

1. IntroductionChronic granulomatous disease (CGD) is a rare inherited immunodeficiency with an estimated incidence of 1 in about 250,000 individuals worldwide [1,2]. Clinically, CGD is characterized by severe recurrent bacterial and fungal infections, which remain the most significant cause of early mortality. CGD is caused by a failure of phagocytic leukocytes (macrophages, neutrophils) to generate reactive oxygen species, which are needed to kill phagocytized microorganisms [3].