Ralf Kühn

Aug 22, 2024 | nature.com | Selene Lickfett |Agnieszka Rybak-Wolf |Carmen Menacho |Stephanie Le |Tancredi Massimo Pentimalli |Daniel Oehler | +14 more

AbstractExpansion of the glutamine tract (poly-Q) in the protein huntingtin (HTT) causes the neurodegenerative disorder Huntington’s disease (HD). Emerging evidence suggests that mutant HTT (mHTT) disrupts brain development. To gain mechanistic insights into the neurodevelopmental impact of human mHTT, we engineered male induced pluripotent stem cells to introduce a biallelic or monoallelic mutant 70Q expansion or to remove the poly-Q tract of HTT.

May 28, 2024 | mdpi.com | Frank Schnütgen |Ralf Kühn |Seren Sevim-Wunderlich |Jana Rossius

1. IntroductionChronic granulomatous disease (CGD) is a rare inherited immunodeficiency with an estimated incidence of 1 in about 250,000 individuals worldwide [1,2]. Clinically, CGD is characterized by severe recurrent bacterial and fungal infections, which remain the most significant cause of early mortality. CGD is caused by a failure of phagocytic leukocytes (macrophages, neutrophils) to generate reactive oxygen species, which are needed to kill phagocytized microorganisms [3].

Apr 19, 2024 | nature.com | Evelyne Gout |Kristoffer Weißert |Sandra Ammann |Ralf Kühn |Matthias Richter |Christine Molenda | +3 more

Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01420-5, published online 2 February 2023. In the version of the article initially published, Anja Schütz (Protein Production & Characterization Core Facility, Max-Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany), who produced the recombinant proteins used in this study, was inadvertently omitted from the author list. This has now been corrected in the PDF and HTML versions of the article.

Jan 3, 2024 | nature.com | Tobias Brunner |Frederik Heinrich |Gitta A. Heinz |Thomas Hofer |Mir-Farzin Mashreghi |Ralf Kühn | +5 more

AbstractThe pleiotropic alarmin interleukin-33 (IL-33) drives type 1, type 2 and regulatory T-cell responses via its receptor ST2. Subset-specific differences in ST2 expression intensity and dynamics suggest that transcriptional regulation is key in orchestrating the context-dependent activity of IL-33–ST2 signaling in T-cell immunity.

Feb 22, 2023 | nature.com | Evelyne Gout |Kristoffer Weißert |Sandra Ammann |Ralf Kühn |Matthias Richter |Christine Molenda | +3 more

Correction to: Nature Immunology https://doi.org/10.1038/s41590-023-01420-5. Published online 2 February 2023. In the version of this article originally published, there was an error in the order of magnitude for the units displayed on the y axes of the Figure 4g HBG (g/dl) panel and Figure 4h Triglycerides (mg/dl) panel, where the units now reading “20, 15, 10, 5, 0” and “200, 150, 100, 50, 0” appeared in error as “2,000, 1,500, 1,000, 500, 0” and “20,000, 15,000, 10,000, 5,000, 0,” respectively.