Frank W. Pun

Nov 15, 2024 | biorxiv.org | Christine Lim |Yuqi Bian |Alicia Gonzalez-Diazag |Frank W. Pun

AbstractMembraneless organelles (MLOs) are dynamic macromolecular condensates that act as crucibles to modulate biological process within the cell. Since MLOs form in the absence of lipid membranes, it is important to understand how their effective regulation is achieved by the protein homeostasis (proteostasis) system. To address this question, we report a comprehensive mapping of the proteostasis network (PN) of MLOs, comprising over 220,000 protein-protein interactions.