Christine Lim

1 week ago | journals.plos.org | Christine Lim |Michele Vendruscolo

Fig 7. Central role of mid-stage regulatory proteins in the proteostasis network perturbations in AD. The functional interaction network of AD-associated proteostasis network genes (from all disease stages) are shown. Genes affected in the early stage are depicted as blue nodes; mid stage as beige nodes; and late stage as red nodes.

2 weeks ago | advanced.onlinelibrary.wiley.com | Christine Lim |Yuqi Bian |Alicia Diaz |Alicia Díaz |Frank W. Pun

1 Introduction Membraneless organelles (MLOs) are macromolecular assemblies that lack lipid membranes but are crucial for orchestrating key cellular processes such as gene regulation, RNA metabolism, and response to stress.[1-5] Given their central roles in managing cellular homeostasis, the improper assembly and disassembly of MLOs may impair the optimal functioning of the cell, contributing to pathological phenomena.[4-7] For example, the dysregulated assembly of stress granules has been...

1 month ago | bernama.com | Christine Lim

BUSINESS Japan External Trade Organisation (JETRO) Kuala Lumpur managing director, Koichi Takano By Christine Lim KUALA LUMPUR, May 5 (Bernama) -- Japanese companies are looking to expand in the decarbonisation, healthcare, innovation and service industries in Malaysia. Japan External Trade Organisation (Jetro) Kuala Lumpur managing director Koichi Takano said several companies have made firm commitments to invest for two years, beginning from this year.

2 months ago | biorxiv.org | Christine Lim |John Hardy |Michele Vendruscolo

AbstractAmyloid plaques and neurofibrillary tangles are molecular hallmarks of Alzheimer's disease. According to the amyloid cascade hypothesis, aberrant Aβ and tau behaviours contribute synergistically to accelerate the Alzheimer's pathology. However, the complex molecular mechanisms linking Aβ and tau dysregulation remain to be fully characterised. To address this problem, we investigated the connection between Aβ and tau through the protein homeostasis (proteostasis) network.

Nov 16, 2024 | bernama.com | Christine Lim

By Christine Lim KUALA LUMPUR, Nov 17 (Bernama) -- Malaysia is in a position to demonstrate leadership in ASEAN as the country assumes its chairmanship role next year. Japan External Trade Organisation (Jetro) Kuala Lumpur managing director Koichi Takano said there are expectations and trust in Malaysia’s leadership.